Deborah M. Muoio, PhD, Duke University
Debbie Muoio is Professor in the Departments of Medicine and Pharmacology & Cancer Biology at Duke University, and Director of Basic Science Research at the Duke Molecular Physiology Institute (DMPI). The projects in her laboratory focus on metabolic networks that control muscle and whole-body energy metabolism, with emphasis on mechanisms linking obesity, aging and physical inactivity to mitochondrial dysfunction, insulin resistance and cardiometabolic disease. During the past 15 years, her team has worked closely with the Metabolomics and Biomarkers Core Laboratory at the DMPI to develop and apply mass spectrometry-based molecular profiling tools for metabolic research. Her program features a translational approach that combines basic and clinical sciences with systems physiology and comprehensive bioenergetics to identify and understand molecular signatures that connect mitochondrial performance to disease risk. Dr. Muoio’s laboratory has enjoyed longstanding support from the NIDDK and NHLBI.